Non-Th2 Regulatory T-Cell Control of Th1 Autoimmunity
نویسندگان
چکیده
منابع مشابه
Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy.
T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-beta and interleukin (IL)-10 or by cell-to-ce...
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Naive (precursor) CD4+ helper T cells recognize specific major histocompatibility complex (MHC)–peptide combinations on antigen-presenting cells (APCs) via interactions with the T-cell receptor (TCR), thereby providing the first signal required for activation. The second, costimulatory signal, is provided by accessory molecules expressed on APCs, such as the widely studied B7 family of proteins...
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Exposure of newborn animals to a foreign Ag may result in immunological tolerance to that specific Ag, a phenomenon called neonatal tolerance. We have previously reported that neonatal administration to Brown-Norway rats of mercury, a heavy metal toxicant, induces a dominant tolerance, specific for the chemical otherwise responsible for Th2 cell-mediated autoimmune responses in this susceptible...
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CD4(+) T-cells have been shown to play a central role in immune control of infection with Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4(+) T-cells and CD4(+) T-cell help for the B-cell response are required for control and elimination of infected red blood cells. CD4(+) T-cells are also important for controlling Plasmodium pre-erythrocytic stages through ...
متن کاملTh1 and Th2 cells help CD8 T-cell responses.
Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address these issues, we compared CD8 T-cell responses in the context of Th1 or Th2 help...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2001
ISSN: 0300-9475
DOI: 10.1046/j.1365-3083.2001.00945.x